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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Horio, N. et al.

Horio, Horiguchi,

Retinal blood flow analysis using intraoperative video fluorescein angiography combined with optical fiber-free intravitreal surgery system.

PURPOSE: To report a new method to perform intraoperative video fluorescein angiography (VFA) using an optical fiber-free intravitreal surgery system (OFFISS) and retinal blood flow analysis during surgery. DESIGN: Observational case series. METHODS: Four eyes of four patients with macular edema as a result of branch retinal vein occlusion underwent vitrectomy and intraoperative VFA with a bolus of 0.8 ml fluorescein dye. The segmental blood flow was calculated using dye dilution technique. Intraocular pressure was maintained at 15 mm Hg. RESULTS: The VFA was clearly recorded with stable excitation light and very little eye movement under retrobulbar anesthesia. The segmental blood flow of the affected vessels (6.1 +/- 1.2 pixel(2)/s) was significantly lower than that of the healthy vessels (17.9 +/- 7.9 pixel(2)/s) (P < .05). CONCLUSION: The combination of VFA and OFFISS can facilitate intraoperative VFA, and may be useful for evaluating retinal blood flow during surgery.[1]

References

Retinal blood flow analysis using intraoperative video fluorescein angiography combined with optical fiber-free intravitreal surgery system. Horio, N., Horiguchi, M. Am. J. Ophthalmol. (2004) [Pubmed]

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