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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis.

The Hedgehog (Hh) signaling pathway is involved in the development of many tissues during embryogenesis, but has also been described to function in adult self-renewing tissues. In the immune system, Sonic Hedgehog (Shh) regulates intrathymic T cell development and modulates the effector functions of peripheral CD4(+) T cells. In this study we investigate whether Shh signaling is involved in peripheral B cell differentiation in mice. Shh is produced by follicular dendritic cells, mainly in germinal centers (GCs), and GC B cells express both components of the Hh receptor, Patched and Smoothened. Blockade of the Hh signaling pathway reduces the survival, and consequently the proliferation and Ab secretion, of GC B cells. Furthermore, Shh rescues GC B cells from apoptosis induced by Fas ligation. Taken together, our data suggest that Shh is one of the survival signals provided by follicular dendritic cells to prevent apoptosis in GC B cells.[1]

References

  1. Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis. Sacedón, R., Díez, B., Nuñez, V., Hernández-López, C., Gutierrez-Frías, C., Cejalvo, T., Outram, S.V., Crompton, T., Zapata, A.G., Vicente, A., Varas, A. J. Immunol. (2005) [Pubmed]
 
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