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Phenotypic and genotypic diagnosis of von Willebrand disease: a 2004 update.

In the last two decades, progress in the diagnosis of von Willebrand disease ( VWD) came from the rapidly developing field of molecular techniques that allowed the first phenotype-genotype correlations. In particular, structural and functional defects of von Willebrand factor ( VWF) that underlie VWD type 2 and their molecular basis not only helped to understand the pathophysiology of VWD but also the complex post-translation processing of VWF and the multiple VWF functions. In contrast to the dramatic development of molecular techniques, improvement of methods for phenotypic description, a prerequisite for phenotype-genotype comparisons, has been neglected. The gold standard to differentiate VWD type 2 from type 1 and between diverse type 2 subtypes is the electrophoretic analysis of VWF multimers, a demanding technique that itself is not easily standardized but of crucial relevance for correct classification. This article summarizes the current knowledge on phenotype-genotype correlations as well as up-to-date phenotypic and genotypic methods in the diagnosis of VWD.[1]

References

  1. Phenotypic and genotypic diagnosis of von Willebrand disease: a 2004 update. Schneppenheim, R., Budde, U. Semin. Hematol. (2005) [Pubmed]
 
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