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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon.

Selenium (Se)-containing proteins have important roles in protecting cells from oxidative damage. This work investigated the effects of Se-depletion on the expression of the genes encoding selenoproteins in colonic mucosa from rats fed diets of different Se content and in human intestinal Caco-2 cells grown in Se-adequate or Se-depleted culture medium. Se-depletion produced statistically significant (P<0.05) falls in glutathione peroxidase (GPX) 1 mRNA (60-83%) and selenoprotein W mRNA (73%) levels, a small but significant fall in GPX4 mRNA (17-25%) but no significant change in GPX2. The data show that SelW expression in the colon is highly sensitive to Se-depletion.[1]

References

  1. Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. Pagmantidis, V., Bermano, G., Villette, S., Broom, I., Arthur, J., Hesketh, J. FEBS Lett. (2005) [Pubmed]
 
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