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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

How to study boron biodistribution in liver metastases from colorectal cancer.

The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: alpha particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.[1]

References

  1. How to study boron biodistribution in liver metastases from colorectal cancer. Roveda, L., Prati, U., Bakeine, J., Trotta, F., Marotta, P., Valsecchi, P., Zonta, A., Nano, R., Facoetti, A., Chiari, P., Barni, S., Pinelli, T., Altieri, S., Braghieri, A., Bruschi, P., Fossati, F., Pedroni, P. Journal of chemotherapy (Florence, Italy) (2004) [Pubmed]
 
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