Interferon-gamma levels in familial Mediterranean fever.
AIMS: To evaluate the levels of endogenous interferon-gamma (IFN-gamma) in patients with familial Mediterranean fever ( FMF). METHODS: Plasma levels of IFN-gamma were assayed in 29 FMF patients in attack-free period (mean age: 32, min-max: 17-48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min-max: 19-50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 +/- 1.50, min-max: 23-42; male/female: 11/8). IFN-gamma levels were also compared among colchicine treated and untreated groups. RESULTS: Median plasma IFN-gamma levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-gamma levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-gamma were comparable in colchicine treated and untreated groups. CONCLUSION: Our results suggest that IFN-gamma may contribute to the inflammatory cascade of FMF.[1]References
- Interferon-gamma levels in familial Mediterranean fever. Köklü, S., Oztürk, M.A., Balci, M., Yüksel, O., Ertenli, I., Kiraz, S. Joint, bone, spine : revue du rhumatisme. (2005) [Pubmed]
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