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Kawai, K. et al.

Kawai, Tsuno, Kitayama, Okaji, Yazawa, Asakage, Yamashita, Watanabe, Takahashi, Nagawa,

Anti-angiogenic properties of plaunotol.

We have investigated a potential anti-angiogenic effect of plaunotol, an extract from the leaves of Plau-noi, in an angiogenesis model consisting of human umbilical vein endothelial cells (HUVECs). Plaunotol inhibited the proliferative activity of HUVECs in a dose-dependent manner. In addition, it caused a remarkable decrease of the ability of HUVECs to adhere and spread on gelatin and vitronectin, but not fibronectin. Tube-like formation in Matrigel was also inhibited in a dose-dependent way. These results strongly suggest the specific inhibition of integrin alphavbeta3 to be the main event of plaunotol-induced suppression of angiogenesis. The alphavbeta3 antagonists are known to be potent inhibitors of tumor angiogenesis and plaunotol, by causing the functional inhibition of alphavbeta3, should be considered a promising new anti-angiogenic drug.[1]

References

Anti-angiogenic properties of plaunotol. Kawai, K., Tsuno, N.H., Kitayama, J., Okaji, Y., Yazawa, K., Asakage, M., Yamashita, H., Watanabe, T., Takahashi, K., Nagawa, H. Anticancer Drugs (2005) [Pubmed]

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