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Leucine-rich nuclear-export signals: born to be weak.

CRM1 mediates the nuclear export of proteins exposing leucine-rich nuclear-export signals (NESs). Most NESs bind to CRM1 with relatively low affinity. Recently, higher-affinity NESs were selected from a 15-mer random peptide library. Unexpectedly, complexes between high-affinity NESs and CRM1 accumulate at the cytoplasmic filaments of the nuclear pore complex (NPC). This finding suggests that high-affinity NES binding to CRM1 impairs the efficient release of export complexes from the NPC, explaining why leucine-rich NESs have evolved to be weak.[1]

References

  1. Leucine-rich nuclear-export signals: born to be weak. Kutay, U., Güttinger, S. Trends Cell Biol. (2005) [Pubmed]
 
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