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Galibert, L. et al.

Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule.

Dendritic cells (DCs) are a phenotypically and functionally heterogenous population of leukocytes with distinct subsets serving a different set of specialized immune functions. Here we applied an in vitro whole cell panning approach using antibody phage display technology to identify cell-surface epitopes specifically expressed on human blood BDCA3(+) DCs. A single-chain antibody fragment (anti-1F12 scFv) was isolated that recognizes a conserved surface antigen expressed on both human BDCA3(+) DCs and mouse CD8alpha(+) DCs. We demonstrate that anti-1F12 scFv binds Nectin-like protein 2 ( Necl2, Tslc1, SynCaM, SgIGSF, or Igsf4), an adhesion molecule involved in tumor suppression, synapse formation, and spermatogenesis. Thus, Necl2 defines a specialized subset of DCs in both mouse and human. We further show that Necl2 binds Class-I-restricted T-cell-associated molecule ( CRTAM), a receptor primarily expressed on activated cytotoxic lymphocytes. When present on antigen presenting cells, Necl2 regulates IL-22 expression by activated CD8(+) T-cells. We propose that Necl2/ CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system.[1]

References

Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. Galibert, L., Diemer, G.S., Liu, Z., Johnson, R.S., Smith, J.L., Walzer, T., Comeau, M.R., Rauch, C.T., Wolfson, M.F., Sorensen, R.A., Van der Vuurst de Vries, A.R., Branstetter, D.G., Koelling, R.M., Scholler, J., Fanslow, W.C., Baum, P.R., Derry, J.M., Yan, W. J. Biol. Chem. (2005) [Pubmed]

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