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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pharmacokinetics of antiviral agents for the treatment of cytomegalovirus infection.

PURPOSE: The mechanism of action, pharmacokinetics, and other advantages and disadvantages of ganciclovir and valganciclovir are discussed. SUMMARY: Shortcomings of oral ganciclovir include low bioavailability, large pill burden, patient nonadherence, and the emergence of resistance. Valganciclovir, an oral prodrug of ganciclovir, has a nearly tenfold greater absolute bioavailability than ganciclovir. Dosage adjustment is required for both drugs in patients with renal impairment. CONCLUSION: The pharmacokinetic profile of valganciclovir offers significant advantages for its use in cytomegalovirus (CMV) prophylaxis.[1]


  1. Pharmacokinetics of antiviral agents for the treatment of cytomegalovirus infection. Baillie, G.M. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. (2005) [Pubmed]
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