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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Perchloric acid-soluble protein regulates cell proliferation and differentiation in the spinal cord of chick embryos.

The role of perchloric acid-soluble protein (PSP) was investigated in chick embryos. Fluorescently labeled anti-chick liver (CL)-PSP IgG was injected into the yolk sac in ovo at embryonic day 3, and became localized in neuroepithelial cells. Within 12 h, morphological changes were observed in 37.5% of anti-CL-PSP IgG-injected embryos, and the neuroepithelial cells formed a wavy line. No significant changes were observed in embryos injected with non-immune IgG or PBS. Increased expression of PCNA and decreased expression of neuronal class III beta-tubulin were observed in the spinal cord after anti-CL-PSP IgG injection. These results suggest that PSP controls the proliferation and differentiation of neuroepithelial cells in chick embryos.[1]

References

  1. Perchloric acid-soluble protein regulates cell proliferation and differentiation in the spinal cord of chick embryos. Himeno, E., Yamazaki, K., Kanouchi, H., Matsumoto, M., Sugimoto, Y., Oka, T. FEBS Lett. (2005) [Pubmed]
 
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