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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Mast cells and endothelin-1: a life-saving biological liaison?

Over a decade ago endothelin-1 ( ET-1) was described as belonging to the assortment of mast cell-derived and mast cell-bound cytokines. Mast cell subtype- and environment-dependent, ET-1 acts as a potent non-immunological mast-cell activator, which leads to degranulation and mediator release. The biological significance of this phenomenon remained obscure; however, a recent report sheds new light on this delicate mast cell- ET-1 connection. The authors of this report use mast cell-deficient mice to provide convincing evidence that mast cells counteract the toxicity induced by high concentrations of ET-1, and thereby promote homeostasis.[1]

References

  1. Mast cells and endothelin-1: a life-saving biological liaison? Hültner, L., Ehrenreich, H. Trends Immunol. (2005) [Pubmed]
 
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