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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Lactococcus lactis SpOx spontaneous mutants: a family of oxidative-stress-resistant dairy strains.

Numerous industrial bacteria generate hydrogen peroxide (H(2)O(2)), which may inhibit the growth of other bacteria in mixed ecosystems. We isolated spontaneous oxidative-stress-resistant (SpOx) Lactococcus lactis mutants by using a natural selection method with milk-adapted strains on dairy culture medium containing H(2)O(2). Three SpOx mutants displayed greater H(2)O(2) resistance. One of them, SpOx3, demonstrated better behavior in different oxidative-stress situations: (i) higher long-term survival upon aeration in LM17 and milk and (ii) the ability to grow with H(2)O(2)-producing Lactobacillus delbrueckii subsp. delbrueckii strains. Furthermore, the transit kinetics of the SpOx3 mutant in the digestive tract of a human flora-associated mouse model was not affected.[1]

References

  1. Lactococcus lactis SpOx spontaneous mutants: a family of oxidative-stress-resistant dairy strains. Rochat, T., Gratadoux, J.J., Corthier, G., Coqueran, B., Nader-Macias, M.E., Gruss, A., Langella, P. Appl. Environ. Microbiol. (2005) [Pubmed]
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