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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3.

Stress-activated protein kinase-3 ( SAPK3) is unique amongst the mitogen-activated protein kinase ( MAPK) family with its C-terminal 5 amino acids directing interaction with the PDZ domain-containing substrates alpha1-Syntrophin and SAP90/PSD95. Here, we identify three additional PDZ domain-containing binding partners, Lin-7C, Scribble, and outer membrane protein 25 ( OMP25). This latter protein is localised together with SAPK3 at the mitochondria but it is not a SAPK3 substrate. Instead, OMP25 inhibits SAPK3 activity towards PDZ domain-containing substrates such as alpha1-Syntrophin and substrates without PDZ domains such as the mitochondrial protein Sab. This is a new mechanism for the regulation of SAPK3 and suggests that its intracellular activity should not be solely assessed by its phosphorylation status.[1]

References

  1. Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3. Court, N.W., Ingley, E., Klinken, S.P., Bogoyevitch, M.A. Biochim. Biophys. Acta (2005) [Pubmed]
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