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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Prepubertal chronic ethanol administration alters TTF-1 and Oct-2 expression in the hypothalamus of female rats.

We found that prolonged administration of ethanol (3 g/kg i.p. at 08:00, once per day) to young female rats starting on postnatal day 24 caused delayed puberty. We further found that prolonged ethanol administration changed the typical hypothalamic expression patterns of TTF-1 and Oct-2 and reduced GnRH mRNA expression. We suggest that these changes may cause the ethanol-induced disturbances in the regulation of GnRH in the hypothalamus and may be responsible for the ethanol-induced reduction in GnRH and LH associated with delayed puberty.[1]

References

  1. Prepubertal chronic ethanol administration alters TTF-1 and Oct-2 expression in the hypothalamus of female rats. Kim, H.J., Sohn, H.J., Ha, M., Han, J.Y., Kang, S.S., Choi, W.S., Cho, G.J. Brain Res. Mol. Brain Res. (2005) [Pubmed]
 
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