A new view of an old pore.
Despite reports suggesting a potential role in membrane fusion, the V(0) subunit of the (+)H/ ATPase has remained an unlikely candidate for the fusion pore. In this issue of Cell, Hiesinger and coworkers (Hiesinger et al., 2005) present a forward genetic screen that reveals it to be necessary for synaptic vesicle fusion, independent of its role in vesicle acidification.[1]References
- A new view of an old pore. Bajjalieh, S. Cell (2005) [Pubmed]
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