Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Völzke, H. et al.

Völzke, Wolff, Grimm, Robinson, Schuster, Herrmann, Motz, Rettig,

Interaction between factor V Leiden and serum LDL cholesterol increases the risk of atherosclerosis.

OBJECTIVES: We investigated the association between the factor V Leiden gene variant and carotid atherosclerosis in a cross-sectional study and explored possible associations between this gene variant and coronary artery disease (CAD) in a case-control study. METHODS: The presence (n=1696) or absence (n=703) of carotid atherosclerosis were sonographically assessed among participants of the population-based Study of Health in Pomerania (SHIP). The case-control study included 1021 patients with severe CAD and 2791 healthy SHIP participants. The factor V Leiden gene variant was determined by PCR and MnlI digestion. RESULTS: Multivariable analyses revealed no independent association between the factor V Leiden gene variant per se and carotid atherosclerosis or CAD. In the cross-sectional study, there was an interaction between the factor V Leiden gene variant and serum LDL cholesterol in non-diabetics with respect to the risk of carotid atherosclerosis. In the case-control study a similar interaction was found for CAD. In both studies the atherosclerotic risk increased with rising serum LDL cholesterol concentrations in carriers of the factor V Leiden gene variant. CONCLUSION: The co-existence between the factor V Leiden gene variant and high serum LDL cholesterol is independently associated with the risk of atherosclerosis.[1]

References

Interaction between factor V Leiden and serum LDL cholesterol increases the risk of atherosclerosis. Völzke, H., Wolff, B., Grimm, R., Robinson, D.M., Schuster, G., Herrmann, F.H., Motz, W., Rettig, R. Atherosclerosis (2005) [Pubmed]

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