Antibody avidity maturation during severe acute respiratory syndrome-associated coronavirus infection

J Infect Dis. 2005 Jul 1;192(1):166-9. doi: 10.1086/430615. Epub 2005 May 25.

Abstract

The maturation of virus-specific immunoglobulin G avidity during severe acute respiratory syndrome-associated coronavirus infection was examined. The avidity indices were low (mean +/- SD, 30.8% +/- 11.6%) among serum samples collected < or =50 days after fever onset, intermediate (mean +/- SD, 52.1% +/- 14.1%) among samples collected between days 51 and 90, and high (mean +/- SD, 78.1% +/- 8.0%) among samples collected after day 90. Avidity indices of 40% and 55% could be considered as cutoff values for determination of recent (< or =50 days) and past (>65 days) infection, respectively. Measurement of antibody avidity can be used to differentiate primary infection from reexposure and to assess humoral responses to candidate vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Viral / physiology*
  • Antibody Affinity / physiology*
  • Female
  • Humans
  • Immunoglobulin G / physiology*
  • Male
  • Middle Aged
  • Severe Acute Respiratory Syndrome / immunology*
  • Severe acute respiratory syndrome-related coronavirus / immunology
  • Time Factors

Substances

  • Antibodies, Viral
  • Immunoglobulin G