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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol.

Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (-)-2,3-O-isopropylidene-D-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps.[1]

References

  1. Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol. Jeong, B.S., Choi, N.S., Ahn, S.K., Bae, H., Kim, H.S., Kim, D. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
 
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