The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

About

Terms

 

 
 
 
 

Differential expression and secretion of bovine serum amyloid A3 (SAA3) by mammary epithelial cells stimulated with prolactin or lipopolysaccharide.

Serum amyloid A ( SAA) proteins were originally identified as prominent acute phase serum reactants synthesized predominately by hepatocytes in response to infection, inflammation and trauma. In this study, we report the differential expression and secretion of serum amyloid A3 (SAA3) by bovine mammary epithelial cells following stimulation with either prolactin ( PRL) or lipopolysaccharide (LPS). Reverse transcription-polymerase chain reaction analysis of PRL or LPS induced bovine mammary epithelial cells resulted in the detection of only the mammary-derived Saa3 (M-Saa3) transcript. Two-dimensional immunoblot analyses of colostrum and milk from healthy cows, as well as conditioned medium from PRL or LPS stimulated bovine mammary epithelial cells confirmed the differential production and secretion of M-SAA3 while other SAA isoforms were not detected. These data indicate that the bovine Saa3 gene is regulated differently from the other Saa genes with regard to the site of and stimulus for expression, suggesting an important tissue-specific function for bovine M-SAA3 during lactation and mammary infection.[1]

References

  1. Differential expression and secretion of bovine serum amyloid A3 (SAA3) by mammary epithelial cells stimulated with prolactin or lipopolysaccharide. Larson, M.A., Weber, A., Weber, A.T., McDonald, T.L. Vet. Immunol. Immunopathol. (2005) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities