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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase.

We evaluated the role of D-amino-acid oxidase on spatial learning and long-term potentiation (LTP) in the hippocampus, since this enzyme metabolizes D-amino-acids, some of which enhance the N-methyl-D-aspartate receptor functions. The Morris water maze learning and the LTP in the CA1 area of the hippocampal slice were observed in wild-type mice and mutant mice lacking D-amino-acid oxidase. The mutant mice showed significantly shorter platform search times in the water maze and significantly larger hippocampal LTPs than the wild-type mice. These results suggest that the abundant D-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning.[1]

References

  1. Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase. Maekawa, M., Watanabe, M., Yamaguchi, S., Konno, R., Hori, Y. Neurosci. Res. (2005) [Pubmed]
 
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