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Bartosik-Psujek, H. et al.

Bartosik-Psujek, Stelmasiak,

The CSF levels of total-tau and phosphotau in patients with relapsing-remitting multiple sclerosis.

Total-tau protein is considered the marker of axon damage whereas the abnormally phosphorylated tau forms are mainly associated with Alzheimer's disease. An increase in total-tau levels was observed in neurodegenerative diseases, including multiple sclerosis ( MS). In order to find out whether the phosphorylated tau forms occur in MS patients and to evaluate their clinical significance, the levels of total-tau (t-tau) and tau phosphorylated at Thr 181 (p-tau) were determined in 60 MS patients (40 during relapse including 18 with the first relapse and 20 stable) and in 18 age-matched controls. The determinations were conducted in the cerebrospinal fluid (CSF) using the ELISA method. The levels of t-tau and p-tau were higher in MS patients than in controls; however, increased levels were not related to the clinical activity of the disease. In CSF of the patients with the first relapse the level of t-tau was significantly increased whilst the level of p-tau was not elevated.[1]

References

The CSF levels of total-tau and phosphotau in patients with relapsing-remitting multiple sclerosis. Bartosik-Psujek, H., Stelmasiak, Z. Journal of neural transmission (Vienna, Austria : 1996) (2006) [Pubmed]

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