Comparison of susceptibility of fungal isolates to lufenuron and nikkomycin Z alone or in combination with itraconazole.
OBJECTIVE: To evaluate and compare the in vitro antifungal properties of lufenuron and nikkomycin Z against isolates of Coccidioides immitis and Aspergillus fumigatus when used singly and in combination with the azole antifungal agent itraconazole. SAMPLE POPULATION: 3 clinical isolates of A fumigatus and the Silveira strain of C immitis. PROCEDURE: The fungal isolates were tested in vitro for susceptibility to the single and combination of compounds by use of microtiter-format susceptibility methods. Minimum inhibitory concentration end points were determined visually, and the contents of representative wells were examined microscopically for evidence of morphologic effects on fungi. RESULTS: No evidence of inhibition, either by susceptibility testing or direct microscopic examination of treated cells, was obtained with lufenuron under experimental conditions. In contrast, nikkomycin Z, a known inhibitor of fungal chitin synthesis, had potent activity against C immitis when used singly. A synergistic interaction between nikkomycin Z and itraconazole was found against isolates of both species tested. CONCLUSIONS AND CLINICAL RELEVANCE: On the basis of our in vitro data, lufenuron does not appear to possess antifungal properties.[1]References
- Comparison of susceptibility of fungal isolates to lufenuron and nikkomycin Z alone or in combination with itraconazole. Hector, R.F., Davidson, A.P., Johnson, S.M. Am. J. Vet. Res. (2005) [Pubmed]
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