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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users.

Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.[1]

References

  1. High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Kim, D.J., Roh, S., Kim, Y., Yoon, S.J., Lee, H.K., Han, C.S., Kim, Y.K. Neurosci. Lett. (2005) [Pubmed]
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