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Conkright, M.D. et al.

CREB: the unindicted cancer co-conspirator.

The transcription factor cAMP response-element binding protein ( CREB) participates in a diverse array of cellular processes, including survival, proliferation and glucose metabolism. A new report by Shankar et al. shows that patients with acute myeloid leukemia ( AML) have a greater incidence of relapse when intracellular levels of CREB are elevated. By enhancing expression of certain cell-cycle genes, CREB appears to promote growth-factor-independent proliferation and survival of myeloid cells. The results provide new insights into CREB function and suggest potential avenues for therapeutic intervention.[1]

References

CREB: the unindicted cancer co-conspirator. Conkright, M.D., Montminy, M. Trends Cell Biol. (2005) [Pubmed]

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