The glycemic index of foods influences postprandial insulin-like growth factor-binding protein responses in lean young subjects.
BACKGROUND: Growth in normal and malignant tissues has been linked to hyperinsulinemia and insulin-like growth factors (IGFs). We hypothesized that IGF and IGF-binding protein (IGFBP) responses may be acutely affected by differences in the glycemic index (GI) of foods. OBJECTIVE: We compared the postprandial responses of IGFs and IGFBP to 2 foods of similar macronutrient composition but with greatly different GIs-pearled barley (GI: 25) and instant mashed potato (GI: 85). DESIGN: Ten young lean subjects consumed 50-g carbohydrate portions of the 2 foods or water (extended fast) in random order after an overnight fast. Capillary blood was collected at regular intervals over 4 h for measurement of blood glucose, insulin, and components of the IGF system. RESULTS: Serum IGFBP-1 declined markedly after both meals, but the mean (+/-SEM) change at 4 h was significantly (P < 0.01) more prolonged after the low-GI meal (-55 +/- 20 ng/mL) than after the high-GI meal (-13 +/- 15 ng/mL). Conversely, the change in serum IGFBP-3 concentration at 4 h was significantly (P < 0.05) higher after the low-GI meal (251 +/- 102 ng/mL) than after the high-GI meal (-110 +/- 96 ng/mL); the same pattern was observed at 2 h. Changes in IGFBP-2, free IGF-1, and total IGF-1 responses were minimal and did not differ significantly from those during the 4-h fast. CONCLUSION: Acute changes in IGFBP-3 after low-GI and high-GI foods may provide a biologic mechanism linking cell multiplication with greater consumption of high-GI carbohydrates.[1]References
- The glycemic index of foods influences postprandial insulin-like growth factor-binding protein responses in lean young subjects. Brand-Miller, J.C., Liu, V., Petocz, P., Baxter, R.C. Am. J. Clin. Nutr. (2005) [Pubmed]
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