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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies.

We describe a 48-year-old woman with seronegative myasthenia gravis (MG) and high-titer of anti-MuSK antibody. She had severe bulbar and respiratory weakness with minimal limb weakness for 2 years. Her disease responded poorly to all the conventional immunosuppressive regimens. Treatment with immunoablative dose of cyclophosphamide led to dramatic and sustained remission of her symptoms. High-dose cyclophosphamide is an effective alternative in patients with unusually refractory disease.[1]

References

  1. High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies. Lin, P.T., Martin, B.A., Weinacker, A.B., So, Y.T. Muscle Nerve (2006) [Pubmed]
 
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