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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

The synthesis and structure-activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with significant therapeutic potential for treating rheumatoid arthritis and other inflammatory diseases.[1]

References

  1. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Gavrin, L.K., Green, N., Hu, Y., Janz, K., Kaila, N., Li, H.Q., Tam, S.Y., Thomason, J.R., Gopalsamy, A., Ciszewski, G., Cuozzo, J.W., Hall, J.P., Hsu, S., Telliez, J.B., Lin, L.L. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
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