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Araki, S. et al.

Araki, Haneda, Sugimoto, Isono, Isshiki, Kashiwagi, Koya,

Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes.

To estimate the frequency of remission/regression of microalbuminuria and to identify factors affecting such outcomes in Japanese patients with type 2 diabetes, we observed 216 patients with type 2 diabetes and microalbuminuria enrolled during an initial 2-year evaluation period for the next 6 years. Remission was defined as shift to normoalbuminuria and regression as a 50% reduction in urinary albumin excretion rate (AER) from one 2-year period to the next. Reduction of urinary AER was frequent, with a 6-year cumulative incidence of 51% (95% CI 42-60) for remission and 54% (45-63) for regression, whereas the frequency of progression to overt proteinuria was 28% (19-37). Microalbuminuria of short duration, the use of renin-angiotensin system-blocking drugs, and lower tertiles for HbA(1c) (<6.95%) and systolic blood pressure (<129 mmHg) were independently associated with remission or regression in the pooled logistic regression analysis. The results indicate that reduction in urinary AER occurs frequently in Japanese patients with type 2 diabetes. Early detection of microalbuminuria and a multifactorial control may result in improved outcomes for diabetic nephropathy and cardiovascular events.[1]

References

Factors associated with frequent remission of microalbuminuria in patients with type 2 diabetes. Araki, S., Haneda, M., Sugimoto, T., Isono, M., Isshiki, K., Kashiwagi, A., Koya, D. Diabetes (2005) [Pubmed]

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