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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster.

A long-standing model postulates that X-chromosome dosage compensation in Drosophila occurs by twofold up-regulation of the single male X, but previous data cannot exclude an alternative model, in which male autosomes are down-regulated to balance gene expression. To distinguish between the two models, we used RNA interference to deplete Male-Specific Lethal ( MSL) complexes from male-like tissue culture cells. We found that expression of many genes from the X chromosome decreased, while expression from the autosomes was largely unchanged. We conclude that the primary role of the MSL complex is to up-regulate the male X chromosome.[1]

References

  1. Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster. Hamada, F.N., Park, P.J., Gordadze, P.R., Kuroda, M.I. Genes Dev. (2005) [Pubmed]
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