- Hepatocyte nuclear factor-1{alpha} is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Bosse, T., van Wering, H.M., Gielen, M., Dowling, L.N., Fialkovich, J.J., Piaseckyj, C.M., Gonzalez, F.J., Akiyama, T.E., Montgomery, R.K., Grand, R.J., Krasinski, S.D. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)