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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation.

Neuronal cell differentiation alterations induced by mutant presenilin 2 ( PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with elevated ryanodine-receptor (RyR) expression and intracellular calcium levels. Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but caffeine, an activator of RyR, exacerbated PS2 mutation-induced interference with cell differentiation. Our results indicate that mutant PS2 inhibits normal neuronal cell differentiation and that RyR-mediated calcium overrelease may be a significant factor.[1]

References

  1. Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation. Lee, S.M., Lee, J.W., Song, Y.S., Hwang, D.Y., Kim, Y.K., Nam, S.Y., Kim, D.J., Yun, Y.W., Yoon, d.o. .Y., Hong, J.T. J. Neurosci. Res. (2005) [Pubmed]
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