Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Kuekrek, H. et al.

Differential effect of interleukin-2 treatment on primary and secondary immunizations in HIV infected individuals.

OBJECTIVES: As interleukin (IL)-2 therapy increases CD4 cell counts in HIV infected subjects, it emerged as a candidate for the partial restoration of immune competence in this disease. METHODS: We studied the frequencies of antigen-specific T cells using single cell resolution cytokine ELISPOT assays and titers of specific antibodies before and after immunization of HIV infected subjects who were treated with HAART or HAART plus IL-2. RESULTS: Subjects seronegative to hepatitis A were vaccinated with hepatitis A antigen. In the non-IL-2 treated group, hepatitis A-specific T cells producing IL-2 and IL-4 along with specific antibodies were induced, showing that these subjects are immune competent and capable of mounting a primary immune response. Additional IL-2 treatment had no significant effect on this primary T cell response; however, booster immunizations with tetanus toxoid or the gp120 depleted HIV vaccine Remune induced higher frequencies of specific interferon (IFN)-gamma producing T cells in IL-2 treated subjects. No impact of IL-2 treatment on these secondary B cell responses was seen. CONCLUSION: Overall, our study showed that IL-2 therapy had no immune enhancing effect on the induction of a primary response, but increased the frequency of IFN-gamma producing memory cells after booster immunization.[1]

References

Differential effect of interleukin-2 treatment on primary and secondary immunizations in HIV infected individuals. Kuekrek, H., Schlingmann, T., Valdez, H., Boehm, B.O., Pollard, R.B., Mitsuyasu, R., Goebel, F.D., Lederman, M.M., Lehmann, P.V., Tary-Lehmann, M. AIDS (2005) [Pubmed]

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