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Technology insight: Application of molecular techniques to formalin-fixed paraffin-embedded tissues from breast cancer.

Breast cancer is a heterogenous disease in terms of both clinical behavior and molecular characteristics. To develop prognostic and predictive markers for breast cancer, it would be useful to be able to analyze formalin-fixed paraffin-embedded tissue (FPET) collected and banked from completed clinical trials. RNAs extracted from FPETs are chemically modified and fragmented, and are therefore not ideal substrates for gene-expression profiling assays. However, methods are being developed to optimize the use of such RNAs for high-throughput gene expression profiling assays. For microarray analysis, existing methods may be adequate for fresh FPET, but they do not work well with older FPET. For older samples, real-time reverse transcription-polymerase chain reaction is the method of choice for gene-expression profiling.[1]

References

  1. Technology insight: Application of molecular techniques to formalin-fixed paraffin-embedded tissues from breast cancer. Paik, S., Kim, C.Y., Song, Y.K., Kim, W.S. Nature clinical practice. Oncology. (2005) [Pubmed]
 
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