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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cohesin and the maternal age effect.

During meiosis in human oocytes, chromosome nondisjunction increases with maternal age, leading to disorders such as Down's syndrome. In a recent study in Nature Genetics, Hodges et al. (2005) show that mice with a mutation in the meiosis-specific cohesin protein SMC1beta exhibit age-dependent defects in meiosis. These defects are similar to those observed in oocytes of older human mothers. Their results implicate an age-dependent loss of function in SMC1beta (or related proteins) in the maternal age effect of humans.[1]


  1. Cohesin and the maternal age effect. Gilliland, W.D., Hawley, R.S. Cell (2005) [Pubmed]
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