Detection of Helicobacter pylori in the middle ear fluid of patients with otitis media with effusion

Otolaryngol Head Neck Surg. 2005 Nov;133(5):791-4. doi: 10.1016/j.otohns.2005.05.050.

Abstract

Objectives: In patients with otitis media with effusion (OME), colonization of the middle ear effusion (MEE) by Helicobacter pylori (HP) was investigated.

Study design: A prospective nonrandomized study with nonpaired, nonmatched controls. Smear preparations were immunostained with anti-HP antibody and were subjected to Gram staining and Giemsa staining. The rapid urease test (CLO) was done.

Results: Twelve of 15 smears for MEE were positive for HP by immunohistochemistry and 14 by Giemsa that were Gram-negative. In 3 with positive immunohistochemistry, the CLO was positive.

Conclusion: The results suggest that HP may exist in the MEE of some patients with OME.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Biopsy, Needle
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Helicobacter Infections / diagnosis*
  • Helicobacter Infections / epidemiology
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Immunohistochemistry
  • Incidence
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Nasal Lavage Fluid / microbiology*
  • Otitis Media with Effusion / diagnosis
  • Otitis Media with Effusion / epidemiology*
  • Otitis Media with Effusion / microbiology*
  • Prospective Studies
  • Reference Values
  • Sex Distribution