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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The enigmatic role of Sir2 in aging.

In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.[1]

References

  1. The enigmatic role of Sir2 in aging. Kennedy, B.K., Smith, E.D., Kaeberlein, M. Cell (2005) [Pubmed]
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