- Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. Agirre, X., Román-Gómez, J., Vázquez, I., Jiménez-Velasco, A., Garate, L., Montiel-Duarte, C., Artieda, P., Cordeu, L., Lahortiga, I., Calasanz, M.J., Heiniger, A., Torres, A., Minna, J.D., Prósper, F. Int. J. Cancer (2006)