Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Taylor, B.A. et al.

Taylor, Tofler, Carey, Morel-Kopp, Philcox, Carter, Elliott, Kull, Ward, Schenck,

Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk.

Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied 67 adults with advanced periodontitis requiring full-mouth tooth extraction. Blood samples were obtained: (1) at initial presentation, immediately prior to treatment of presenting symptoms; (2) one to two weeks later, before all teeth were removed; and (3) 12 weeks after full-mouth tooth extraction. After full-mouth tooth extraction, there was a significant decrease in C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen, and white cell and platelet counts. This study shows that elimination of advanced periodontitis by full-mouth tooth extraction reduces systemic inflammatory and thrombotic markers of cardiovascular risk. Analysis of the data supports the hypothesis that treatment of periodontal disease may lower cardiovascular risk, and provides a rationale for further randomized studies.[1]

References

Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk. Taylor, B.A., Tofler, G.H., Carey, H.M., Morel-Kopp, M.C., Philcox, S., Carter, T.R., Elliott, M.J., Kull, A.D., Ward, C., Schenck, K. J. Dent. Res. (2006) [Pubmed]

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