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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Apolipoprotein D is associated with long-term outcome in patients with schizophrenia.

Accumulating evidence implicates deficiencies in apolipoprotein D (ApoD) function and arachidonic acid signaling in schizophrenic disorders. We addressed two hypotheses in relation to ApoD: first, polymorphisms in the ApoD gene confer susceptibility to or are markers of disease, and, second, genetic variation in the ApoD is associated with long-term clinical outcome to antipsychotic treatment. We genotyped two single-nucleotide polymorphisms in the ApoD gene in 343 chronic patients with schizophrenia spectrum disorders (ICD-10) and 346 control subjects of Danish origin. We did not find ApoD alleles, genotypes or haplotypes to be associated with disease. However, we did find that long-term clinical outcome was associated with the ApoD polymorphism rs7659 (P = 0.041) following adjustment for lifetime clinical global impression, age at first admission and gender.[1]

References

  1. Apolipoprotein D is associated with long-term outcome in patients with schizophrenia. Hansen, T., Hemmingsen, R.P., Wang, A.G., Olsen, L., Timm, S., Søeby, K., Jakobsen, K.D., Fenger, M., Parnas, J., Rasmussen, H.B., Werge, T. Pharmacogenomics J. (2006) [Pubmed]
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