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Sandstedt, S.A. et al.

Sandstedt, Tucker,

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

Two related genes with potentially similar functions, one on the Y chromosome and one on the X chromosome, were examined to determine if they evolved differently because of their chromosomal positions. Six hundred fifty-seven base pairs of coding sequence of Jarid1d (Smcy) on the Y chromosome and Jarid1c (Smcx) on the X chromosome were sequenced in 13 rodent taxa. An analysis of replacement and silent substitutions, using a counting method designed for samples with small evolutionary distances, showed a significant difference between the two genes. The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties. These findings are similar to results of previous studies of Y chromosomal genes in these and other mammalian taxa, suggesting that genes on the mammalian Y evolve in a chromosome-specific manner.[1]

References

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus. Sandstedt, S.A., Tucker, P.K. Mamm. Genome (2006) [Pubmed]

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