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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Recovery of drug-resistant influenza virus from immunocompromised patients: a case series.

Influenza virus with resistance to antiviral drugs emerges with increased frequency in immunocompromised patients and can limit the benefit of M2 and neuraminidase ( NA) inhibitors. We document 3 cases of influenza in severely immunocompromised patients from whom virus variants with molecular markers of resistance to anti-influenza drugs were recovered. Virus variants recovered from 2 patients had mutations in the M2, NA (with a previously recognized Glu119Val NA substitution), and hemagglutinin genes. We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir.[1]

References

  1. Recovery of drug-resistant influenza virus from immunocompromised patients: a case series. Ison, M.G., Gubareva, L.V., Atmar, R.L., Treanor, J., Hayden, F.G. J. Infect. Dis. (2006) [Pubmed]
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