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Ohtani, T. et al.

Ohtani, Nakamura, Toda, Furukawa,

Cyclophosphamide enhances TNF-alpha-induced apoptotic cell death in murine vascular endothelial cell.

Cyclophosphamide (CPA) is one of the therapeutic agents for systemic inflammatory disorders. In murine dermal endothelial cells (F-2), 4-hydroxycyclophosphamide (4-HC), which is active metabolite of CPA, enhanced TNF-alpha-induced DNA fragmentation. In addition, 4-HC was shown to elevate TNF-alpha- induced caspase-3 activation. Caspase-8 activation was identified by the treatment of TNF-alpha, whereas 4-HC was no effect. In contrast, only when treated with 4-HC, caspase-9 activation and the increase in the intracellular expression of Bax were detected. These results suggest that CPA may sensitize endothelial cells to TNF-alpha-induced apoptosis through a mitochondria-dependent pathway and clinically may contribute to the limitation of inflammatory process.[1]

References

Cyclophosphamide enhances TNF-alpha-induced apoptotic cell death in murine vascular endothelial cell. Ohtani, T., Nakamura, T., Toda, K., Furukawa, F. FEBS Lett. (2006) [Pubmed]

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