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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Ng, D. et al.

David Ng, Gerald E. Marti, Laura Fontaine, Jorge R. Toro, Neil Caporaso, Lynn R. Goldin,

High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia.

A subset of chronic lymphocytic leukaemia (CLL) shows familial aggregation. Studies show an increased risk for CLL and other lymphoproliferative disease among first-degree relatives of affected individuals. A genome-wide scan of 18 CLL families in 2003 detected LOD or non-parametric linkage scores > or = 1.0 on chromosomes 1, 3, 6, 12, 13 and 17. Follow-up study with 28 families showed no evidence of linkage at 1p22.1-p21.2, 3q22.1, 3q26.2, 6q22.31-q23.2, 12q24.23, 14q32.13, 17p13. 3. Chromosome 13q21.33 remains a region of interest with a P-value of 0.013 (marker D13S1291) and warrants additional molecular investigation as a susceptibility region for CLL.[1]

References

High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia. Ng, D., Marti, G.E., Fontaine, L., Toro, J.R., Caporaso, N., Goldin, L.R. Br. J. Haematol. (2006) [Pubmed]

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