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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The synchrony phenotype persists after elimination of multiple GATC sites from the dnaA promoter of Escherichia coli.

To examine whether methylation of the GATC sites present in the dnaA promoter region is responsible for the strict temporal coordination of initiation events at oriC as measured by the synchrony of initiation, we introduced point mutations eliminating three (TGW1) and five (TGW2) of the six GATC sites present in the dnaA promoter region. All of the strains containing these mutations, including the one with five GATC sites eliminated, initiated chromosomal replication synchronously.[1]

References

  1. The synchrony phenotype persists after elimination of multiple GATC sites from the dnaA promoter of Escherichia coli. Wilkinson, T.G., Kedar, G.C., Lee, C., Guzmán, E.C., Smith, D.W., Zyskind, J.W. J. Bacteriol. (2006) [Pubmed]
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