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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061.

We analysed viral kinetics from a 2-day treatment with BILN 2061, a serine protease inhibitor of hepatitis C virus, in patients chronically infected with genotype 1 hepatitis C virus. The efficiency (E), describing inhibition of viral production, was above 99.45% in all patients with minor or moderate fibrosis receiving doses of 200mg and 500 mg twice daily and larger than in previous studies for interferon-based treatments. However, epsilon was slightly smaller in patients with cirrhosis given 200mg and markedly smaller in patients given 25 mg. Estimates of viral clearance and infected-cell loss support conclusions on these rates and on treatment mechanisms from previous studies on interferon-alpha-based treatments.[1]

References

  1. Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061. Herrmann, E., Zeuzem, S., Sarrazin, C., Hinrichsen, H., Benhamou, Y., Manns, M.P., Reiser, M., Reesink, H., Calleja, J.L., Forns, X., Steinmann, G.G., Nehmiz, G. Antivir. Ther. (Lond.) (2006) [Pubmed]
 
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