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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties.

Guanidine-based peptide nucleic acid (GPNA) monomers and oligomers containing all four natural (adenine (A), cytosine ( C), guanine ( G), and thymine ( T)) and two unnatural (2-thiouracil (sU) and 2,6-diaminopurine ( D)) nucleobases have been synthesized. Thermal denaturation study showed that GPNA oligomers containing alternate D-backbone configuration bind sequence-specifically to DNA and, when incubated with mammalian cells, localized specifically to the endoplasmic reticulum (ER).[1]

References

  1. Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties. Zhou, P., Dragulescu-Andrasi, A., Bhattacharya, B., O'Keefe, H., Vatta, P., Hyldig-Nielsen, J.J., Ly, D.H. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
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