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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors.

We have performed virtual screening of a chemical database of 508,143 commercially available chemicals to search for new methionyl-tRNA synthetase ( MetRS) inhibitors. In this study, potent lead compounds with a novel skeleton, including compound 27 with IC50 = 237 nM, were successfully identified as Escherichia coli MetRS inhibitors.[1]

References

  1. Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors. Kim, S.Y., Lee, Y.S., Kang, T., Kim, S., Lee, J. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
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