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Casadei, M.A. et al.

Casadei, Cerreto, Cesa, Giannuzzo, Feeney, Marianecci, Paolicelli,

Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations.

Solid lipid nanoparticles (SLN) containing or not (S)-(+)-2-(4-isobutylphenyl)propionic acid (ibuprofen) were prepared with Preciol ATO 5 as lipid phase by the hot homogenization technique and characterized through particle size analyses and zeta potential measurements. DSC experiments carried out on the freeze-dried samples of loaded SLN showed a shift of the melting endotherm of the lipid phase, with the maximum at a temperature value higher then that of the"empty" SLN. (1)H NMR of the nanosuspension allowed to calculate the encapsulation efficiency of the particles that was 52+/-3%. By adding dextran methacrylate (DEX-MA) to the aqueous phase and submitting the mixture to UV irradiation, systems of SLN (drug-loaded and unloaded) incorporated into a dextran hydrogel were prepared. Finally, dissolution studies of ibuprofen from the freeze-dried samples were performed. The comparison among the release profiles of ibuprofen from SLN, DEX-MA hydrogel and SLN/DEX-MA-hydrogel allows to affirm that this last system, retaining about 60% of the drug after 2h in acid medium and releasing it slowly in neutral solution, is suitable for modified delivery oral formulations.[1]

References

Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations. Casadei, M.A., Cerreto, F., Cesa, S., Giannuzzo, M., Feeney, M., Marianecci, C., Paolicelli, P. International journal of pharmaceutics. (2006) [Pubmed]

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