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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.
In multicellular eukaryotes, geminin prevents overreplication of DNA in proliferating cells. Here, we show that genetic ablation of geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplication at eight cells, rather than 32 cells. All cells in geminin-deficient embryos commit to the trophoblastcell lineage and consist of trophoblastgiant cells (TGCs) only. Geminin is also down-regulated in TGCs of wild-type blastocysts during S and gap-like phases by proteasome-mediated degradation, suggesting that loss of geminin is part of the mechanism regulating endoreduplication.[1]
